smart medical doctor hand drawing network with operating room as shutterstock_128456363 shutterstock_264717029 Research & Development Literatur & Papers Literatur der GründerAndere Target bezogene Literatur Willmes et al. 2017 – Pharmacol Ther. Review: The longevity gene INDY (I’m Not Dead Yet) in metabolic control: Potential as pharmacological target von Loeffelholz et al. 2017 – Hepatology The Human Longevity Gene Homolog INDY and Interleukin-6 Interact in Hepatic Lipid Metabolism Brachs et al. 2016 – Molecular Metabolism Inhibition of citrate cotransporter Slc13a5/mINDY by RNAi improves hepatic insulin sensitivity and prevents diet-induced non-alcoholic fatty liver disease in mice Willmes et al. 2016 – Aging The longevity transporter mIndy (Slc13a5) as a target for treating hepatic steatosis and insulin resistance Jordan and Birkenfeld 2016 – Rev Endocr Metab Disord Cardiometabolic crosstalk in obesity-associated arterial hypertension Jordan et al. 2015 – J Hypertension Joint scientific statement of the European Association for the Study of Obesity and the European Society of Hypertension: Obesity and early vascular ageing. Neuschaefer-Rube et al. 2015 – Toxicology Arylhydrocarbon receptor (AhR) dependent mIndy (Slc13a5) induction as possible contributor to benzo[a]pyrene induced lipid accumulation in hepatocytes Schwarz et al. 2015 – Aging Knockdown of Indy/CeNac2 extends Caenorhabditis elegans life span by inducing AMPK/aak‐2. Pesta et al. 2015 – Aging Prevention of diet‐induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5). Neuschaefer-Rube et al. 2013 – Diabetes The Mammalian INDY Homolog is Induced by cAMP responsive-element-binding protein (CREB) in a Rat Model of Type 2 Diabetes. Willmes and Birkenfeld 2013 – Comp Struct Biotech J The Role of INDY in Metabolic Regulation (Review) Birkenfeld et al. 2011 – Cell Metab Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice. Li et al. 2017 – J Biol Chem Silencing of solute carrier family 13 member 5 disrupts energy homeostasis and inhibits proliferation of human hepatocarcinoma cells Rogina 2017 – Frontiers in Genetics INDY-A New Link to Metabolic Regulation in Animals and Humans Pajor et al. 2016 – Molecular Pharmacology Molecular Basis for Inhibition of the Na+/Citrate Transporter NaCT (SLC13A5) by Dicarboxylate Inhibitors Rives et al. 2016 – Molecular Pharmacology State-Dependent Allosteric Inhibition of the Human SLC13A5 Citrate Transporter by Hydroxysuccinic Acids, PF-06649298 and PF-06761281 Huard et al. 2016 – J Med Chem Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family Huard et al. 2015 – Sci Rep Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5) Hardies et al. 2015 – Brain Recessive mutations in SLC13A5 result in a loss of citrate transport and cause neonatal epilepsy, developmental delay and teeth hypoplasia Gopal et al. 2015 – J Pharmacol Exp Ther Species-specific Influence of Lithium on the Activity of SLC13A5 (NaCT): Lithium-induced Activation is Specific for the Transporter in Primates Mancusso et al. 2012 – Nature Structure and mechanism of a bacterial sodium-dependent dicarboxylate transporter (crystal structure of vcINDY, a bacterial homologue of INDY, NaCT). Gopal et al. 2007 – Am J Physiol Gastrointest Liver Physiol Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines. Inoue et al. 2002 – Biochem Biophys Res Comm Human Na+-coupled citrate transporter (NaCT): primary structure, genomic organization, and transport function. Rogina et al. 2000 – Science Extended Life-Span Conferred by Cotransporter Gene Mutations in Drosophila (discovery of INDY: I am Not Dead Yet).
