Literatur der Gründer

von Loeffelholz et al. – Hepatology
The Human Longevity Gene Homolog INDY and Interleukin-6 Interact in Hepatic Lipid Metabolism
Brachs et al. – Molecular Metabolism
Inhibition of citrate cotransporter Slc13a5/mINDY by RNAi improves hepatic insulin sensitivity and prevents diet-induced non-alcoholic fatty liver disease in mice

Willmes et al. 2016 – Aging
The longevity transporter mIndy (Slc13a5) as a target for treating hepatic steatosis and insulin resistance

Jordan and Birkenfeld 2016 – Rev Endocr Metab Disord
Cardiometabolic crosstalk in obesity-associated arterial hypertension

Neuschaefer-Rube et al. 2015 – Toxicology
Arylhydrocarbon receptor (AhR) dependent mIndy (Slc13a5) induction as possible contributor to benzo[a]pyrene induced lipid accumulation in hepatocytes

Schwarz et al. 2015 – Aging
Knockdown of Indy/CeNac2 extends Caenorhabditis elegans life span by inducing AMPK/aak‐2.
Pesta et al. 2015 – Aging
Prevention of diet‐induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5).
Neuschaefer-Rube et al. 2013 – Diabetes
The Mammalian INDY Homolog is Induced by cAMP responsive-element-binding protein (CREB) in a Rat Model of Type 2 Diabetes.

Willmes and Birkenfeld 2013 – Comp Struct Biotech J
The Role of INDY in Metabolic Regulation (Review)
Birkenfeld et al. 2011 – Cell Metab
Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice.

Andere Target bezogene Literatur

Pajor et al. 2016 – Molecular Pharmacology
Molecular Basis for Inhibition of the Na+/Citrate Transporter NaCT (SLC13A5) by Dicarboxylate Inhibitors
Rives et al. 2016 – Molecular Pharmacology
State-Dependent Allosteric Inhibition of the Human SLC13A5 Citrate Transporter by Hydroxysuccinic Acids, PF-06649298 and PF-06761281
Huard et al. 2016 – J Med Chem
Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family
Huard et al. 2015 – Sci Rep
Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)
Hardies et al. 2015 – Brain
Recessive mutations in SLC13A5 result in a loss of citrate transport and cause neonatal epilepsy, developmental delay and teeth hypoplasia

Gopal et al. 2015 – J Pharmacol Exp Ther
Species-specific Influence of Lithium on the Activity of SLC13A5 (NaCT): Lithium-induced Activation is Specific for the Transporter in Primates

Mancusso et al. 2012 – Nature
Structure and mechanism of a bacterial sodium-dependent dicarboxylate transporter (crystal structure of vcINDY, a bacterial homologue of INDY, NaCT).
Gopal et al. 2007 – Am J Physiol Gastrointest Liver Physiol
Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines.

Inoue et al. 2002 – Biochem Biophys Res Comm
Human Na+-coupled citrate transporter (NaCT): primary structure, genomic organization, and transport function.

Rogina et al. 2000 – Science
Extended Life-Span Conferred by Cotransporter Gene Mutations in Drosophila (discovery of INDY: I am Not Dead Yet).